Protein Purification
MilliporeSigma™ Calbiochem™ CCR2 Antagonist
The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
MilliporeSigma™ Calbiochem™ Indirubin-3'-monoxime-5-sulphonic Acid
A potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM).
MilliporeSigma™ Calbiochem™ GM 6001
GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases.
MilliporeSigma™ Calbiochem™ Glucagon-Like Peptide 1 Receptor Agonist II
A pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50
MilliporeSigma™ Calbiochem™ RHC-80267
Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells.
MilliporeSigma™ Calbiochem™ STING Agonist, 2ʹ3ʹ-cGAMP
A cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 =
MilliporeSigma™ Calbiochem™ IRE1 Inhibitor II
The IRE1 Inhibitor II controls the biological activity of IRE1.
MilliporeSigma™ Calbiochem™ InSolution™ H-89, Dihydrochloride
InSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10mm solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48nM).
MilliporeSigma™ Calbiochem™ InSolution™ MG-132 in EtOH, ≥95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
MilliporeSigma™ Calbiochem™ 4α-Phorbol-12,13-didecanoate
Inactive on mouse skin as an inflammatory and tumor-promoting agent.
MilliporeSigma™ Calbiochem™ NS8593
An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.
MilliporeSigma™ Calbiochem™ InSolution™ Cyclopamine, V. californicum
The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ InSolution™ Src Inhibitor, PP1
The InSolution™ Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Transglutaminase 2 Inhibitor II, ERW1041E
A cell-permeable, active-site directed, acyl-donor substrate competitive inhibitor of transglutaminase 2 (TG2, Ki = 11 μM).